|Other Accession||NM_002250, NP_002241|
|Reactivity||Human, Rat, Pig, Horse, Bovine|
|Alias Symbol||IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4|
|Other Names||Intermediate conductance calcium-activated potassium channel protein 4, SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel, KCNN4, IK1, IKCA1, KCA4, SK4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KCNN4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KCNN4 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IK1, IKCA1, KCA4, SK4|
|Function||Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed in non-excitable tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Gao,Y., (2008) J. Biol. Chem. 283 (14), 9049-9059 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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