|Other Accession||NM_002250, NP_002241|
|Reactivity||Human, Rat, Pig, Horse, Bovine|
|Alias Symbol||IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4|
|Other Names||Intermediate conductance calcium-activated potassium channel protein 4, SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel, KCNN4, IK1, IKCA1, KCA4, SK4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KCNN4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KCNN4 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IK1, IKCA1, KCA4, SK4|
|Function||Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed in non-excitable tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Gao,Y., (2008) J. Biol. Chem. 283 (14), 9049-9059 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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