TRPC6 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9Y210 |
Other Accession | NM_004621, NP_004612 |
Reactivity | Human, Mouse, Rat, Pig, Horse, Yeast, Bovine, Dog |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 106kDa |
Gene ID | 7225 |
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Alias Symbol | FLJ11098, FLJ14863, FSGS2, TRP6 |
Other Names | Short transient receptor potential channel 6, TrpC6, Transient receptor protein 6, TRP-6, TRPC6, TRP6 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TRPC6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | TRPC6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRPC6 {ECO:0000303|PubMed:9930701, ECO:0000312|HGNC:HGNC:12338} |
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Function | Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. |
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Provided below are standard protocols that you may find useful for product applications.
References
Liu,D., (2008) Arterioscler. Thromb. Vasc. Biol. 28 (4), 746-751 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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