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TRPC6 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - TRPC6 antibody - middle region AI10797

    WB Suggested Anti-TRPC6 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: MCF7 cell lysate
    detail
  • WB - TRPC6 antibody - middle region AI10797
    TRPC6 antibody - middle region (AI10797) validated by WB using pulmonary artery smooth muscle
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Y210
Other Accession NM_004621, NP_004612
Reactivity Human, Mouse, Rat, Pig, Horse, Yeast, Bovine, Dog
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 106kDa
Additional Information
Gene ID 7225
Alias Symbol FLJ11098, FLJ14863, FSGS2, TRP6
Other Names Short transient receptor potential channel 6, TrpC6, Transient receptor protein 6, TRP-6, TRPC6, TRP6
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-TRPC6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTRPC6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPC6 {ECO:0000303|PubMed:9930701, ECO:0000312|HGNC:HGNC:12338}
Function Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
Research Areas
Citations (0)
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References

Liu,D., (2008) Arterioscler. Thromb. Vasc. Biol. 28 (4), 746-751 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 389.00
Cat# AI10797
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