|Application ||WB, IHC|
|Other Accession||NM_053686, NP_446138|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig|
|Alias Symbol||CaT1, Ecac2, Otrpc3|
|Other Names||Transient receptor potential cation channel subfamily V member 6, TrpV6, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2, Trpv6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Trpv6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Trpv6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:10428857, PubMed:11287959, PubMed:27296226). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:10428857, PubMed:11287959, PubMed:27296226). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Expressed in duodenum, proximal jejunum, cecum, and colon.|
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