|Other Accession||NM_021984, NP_068819|
|Reactivity||Human, Mouse, Rat, Rabbit|
|Predicted||Human, Mouse, Rat, Rabbit|
|Other Names||Gamma-aminobutyric acid receptor subunit epsilon, GABA(A) receptor subunit epsilon, GABRE|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GABRE antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GABRE antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in many tissues. Highest levels of expression in adult heart and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Sinkkonen,S.T., et al., (2000) J. Neurosci. 20 (10), 3588-3595Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Hengen, K. B., Gomez, T. M., Stang, K. M., Johnson, S. M. & Behan, M. Changes in ventral respiratory column GABAaR ε- and δ-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R272-83 (2011). WB, IHC, IP, Human, Rat, Rabbit, Mouse, Guinea pig21084677Hengen, K. B. et al. Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. PLoS One 7, e30608 (2012). WB, IHC, IP, Human, Rat, Rabbit, Mouse, Guinea pig22303446Fatemi, S. H., Folsom, T. D., Rooney, R. J. & Thuras, P. D. Expression of GABAA -alpha2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. Transl. Psychiatry 3, e303 (2013). WB, IHC, IP, Human, Rat, Rabbit, Mouse, Guinea pig24022508
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