|Other Accession||NM_054020, NP_473361|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Dog|
|Predicted||Human, Rabbit, Pig, Bovine|
|Other Names||Cation channel sperm-associated protein 2, CatSper2, CATSPER2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-CATSPER2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CATSPER2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.|
|Cellular Location||Cell projection, cilium, flagellum membrane; Multi-pass membrane protein Note=Specifically located in the principal piece of sperm tail|
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Provided below are standard protocols that you may find useful for product applications.
Quill,T.A., et al., (2001) Proc. Natl. Acad. Sci. U.S.A. 98 (22), 12527-12531Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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