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SLC18A1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P54219 |
| Other Accession | NM_003053, NP_003044 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56kDa |
| Gene ID | 6570 |
|---|---|
| Alias Symbol | CGAT, VAT1, VMAT1 |
| Other Names | Chromaffin granule amine transporter, Solute carrier family 18 member 1, Vesicular amine transporter 1, VAT1, SLC18A1, VAT1, VMAT1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SLC18A1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SLC18A1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC18A1 |
|---|---|
| Synonyms | VAT1, VMAT1 |
| Function | [Isoform 1]: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:23337945, PubMed:8643547, PubMed:16326835). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (PubMed:23337945). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R090}; Multi-pass membrane protein [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed primarily in neuroendocrine tissues. Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level) Found in some paracrine cells in stomach and duodenum (at protein level) (PubMed:8643547). Expressed in substantia nigra (PubMed:23337945). [Isoform 2]: Expressed in gastrointestinal tract. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Horvath,G., et al., (2003) Am. J. Physiol. Lung Cell Mol. Physiol. 285 (4), L829-L837Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 389.00
Cat# AI10863
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