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MOV10L1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - MOV10L1 antibody - N-terminal region AI10986

    WB Suggested Anti-MOV10L1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:12500
    Positive Control: Human Small Intestine
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9BXT6
Other Accession NM_018995, NP_061868
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 135kDa
Additional Information
Gene ID 54456
Alias Symbol DJ402G11.8, DKFZp434B0717, FLJ33421, CHAMP
Other Names Putative helicase Mov10l1, 3.6.4.13, Moloney leukemia virus 10-like protein 1, MOV10-like protein 1, MOV10L1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-MOV10L1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMOV10L1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MOV10L1 (HGNC:7201)
Function ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q99MV5}. Note=Component of the meiotic nuage, also named P granule, a germ- cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV5}
Tissue Location Isoform 1: Specifically expressed in testis.
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References

Collins,J.E., Genome Biol. 5 (10), R84 (2004)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 293.00
Cat# AI10986
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