|Other Accession||NM_033647, NP_387467|
|Reactivity||Human, Rat, Pig, Bovine|
|Other Names||DNA helicase B, hDHB, 220.127.116.11, HELB|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-HELB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HELB antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Unwinds duplex DNA with 5'-3' polarity. Has single- strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.|
|Cellular Location||Note=Preferentially during S phase, recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment|
|Tissue Location||Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain|
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Provided below are standard protocols that you may find useful for product applications.
Taneja,P., et al., (2002) J. Biol. Chem. 277 (43), 40853-40861Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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