|Application ||WB, IHC|
|Other Accession||NM_005916, NP_005907|
|Reactivity||Human, Rat, Rabbit, Horse, Bovine|
|Predicted||Human, Rat, Rabbit, Bovine|
|Alias Symbol||MCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3|
|Other Names||DNA replication licensing factor MCM7, 22.214.171.124, CDC47 homolog, P1.1-MCM3, MCM7, CDC47, MCM2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-MCM7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MCM7 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.|
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Provided below are standard protocols that you may find useful for product applications.
Ren,B., (2006) Oncogene 25 (7), 1090-1098Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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