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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KCTD11 antibody - N-terminal region   

KCTD11 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - KCTD11 antibody - N-terminal region AI11029

    WB Suggested Anti-KCTD11 Antibody Titration: 1.25μg/ml
    ELISA Titer: 1:62500
    Positive Control: HepG2 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q693B1
Other Accession NM_001002914, NP_001002914
Reactivity Human, Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Additional Information
Gene ID 147040
Alias Symbol REN, KCASH1, C17orf36, REN/KCTD11
Other Names BTB/POZ domain-containing protein KCTD11, KCTD11, C17orf36, REN
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-KCTD11 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsKCTD11 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCTD11
Synonyms C17orf36, REN
Function Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Tissue Location Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma
Research Areas
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Di,M., et al., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (29), 10833-10838Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 232.00
Cat# AI11029
(40 western blots)
Availability: 2-3 days
Bulk Size
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