|Other Accession||NM_001002914, NP_001002914|
|Alias Symbol||REN, KCASH1, C17orf36, REN/KCTD11|
|Other Names||BTB/POZ domain-containing protein KCTD11, KCTD11, C17orf36, REN|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-KCTD11 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KCTD11 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.|
|Tissue Location||Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma|
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Provided below are standard protocols that you may find useful for product applications.
Di,M., et al., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (29), 10833-10838Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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