Noto antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | A8MTQ0 |
Other Accession | NM_001007472, NP_001007473 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog |
Predicted | Mouse, Rabbit, Pig, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 26kDa |
Gene ID | 344022 |
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Alias Symbol | Flh, MmNot, Not, tc |
Other Names | Homeobox protein notochord, NOTO |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Noto antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Noto antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NOTO |
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Function | Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
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