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Men1 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Men1 antibody - middle region AI11067

    WB Suggested Anti-Men1 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Mouse Muscle
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O88559
Other Accession NM_008583, NP_032609
Reactivity Human, Mouse, Rat, Pig, Horse, Bovine
Predicted Human, Mouse, Rat, Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 67kDa
Additional Information
Gene ID 17283
Alias Symbol AW045611
Other Names Menin, Men1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Men1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMen1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Men1
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
Cellular Location Nucleus. Note=May be perinuclear in testis.
Tissue Location Widely expressed, with high levels in hippocampus, cerebral cortex, testis and thymus (at protein level). Also expressed at high levels in pancreatic islets, ovary and bone marrow. In the brain, highest expression in hippocampus pyramidal nerve cells (at protein level). In the testis, may be expressed in spermatogonia (at protein level). Low expression, if any, in skeletal muscle.
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$ 293.00
Cat# AI11067
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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