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PTRF antibody - middle region

Rabbit Polyclonal Antibody

  • IHC - PTRF antibody - middle region AI11078
    IHC Information: Paraffin embedded mouse vessel and adipocytes (skeletal muscle) tissue, tested with an antibody Dilution of 5 μg/ml.
  • WB - PTRF antibody - middle region AI11078

    WB Suggested Anti-PTRF Antibody Titration: 0.625μg/ml
    ELISA Titer: 1:312500
    Positive Control: NIH/3T3 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O54724
Other Accession NM_008986, NP_033012
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Additional Information
Gene ID 19285
Alias Symbol Cavin, Cav-p60, AW546441, 2310075E07Rik
Other Names Polymerase I and transcript release factor, Cav-p60, Cavin-1, Ptrf {ECO:0000312|MGI:MGI:1277968}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-PTRF antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPTRF antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ptrf {ECO:0000312|MGI:MGI:1277968}
Function Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.
Cellular Location Membrane, caveola. Cell membrane. Microsome {ECO:0000250|UniProtKB:Q6NZI2}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P85125}. Cytoplasm, cytosol. Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus {ECO:0000250|UniProtKB:Q6NZI2}. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712) {ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712}
Tissue Location Expressed in all tissues tested (lung, heart, testis, kidney, muscle, liver, spleen and brain). Highest levels in lung and heart.
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Miyoshi,K., et al., (2001) Genomics 71 (2), 150-155Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 232.00
Cat# AI11078
Availability: 2-3 days
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