PTRF antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | O54724 |
Other Accession | NM_008986, NP_033012 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 43kDa |
Gene ID | 19285 |
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Alias Symbol | Cavin, Cav-p60, AW546441, 2310075E07Rik |
Other Names | Polymerase I and transcript release factor, Cav-p60, Cavin-1, Ptrf {ECO:0000312|MGI:MGI:1277968} |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 100 ul of distilled water. Final anti-PTRF antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | PTRF antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Cavin1 |
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Synonyms | Ptrf {ECO:0000312|MGI:MGI:1277968} |
Function | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18191225, PubMed:18840361, PubMed:18056712, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA- bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:9582279, PubMed:11139612). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967). |
Cellular Location | Membrane, caveola. Cell membrane. Microsome {ECO:0000250|UniProtKB:Q6NZI2}. Endoplasmic reticulum. Cytoplasm, cytosol Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin- dependent manner (PubMed:19546242). {ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:19546242} |
Tissue Location | Expressed in the heart, stomach, adipose tissue and lung (at protein level). Expressed in testis, kidney, muscle, liver, spleen and brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Miyoshi,K., et al., (2001) Genomics 71 (2), 150-155Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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