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Sfpi1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P17433 |
| Other Accession | NM_011355, NP_035485 |
| Reactivity | Mouse, Rat |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31kDa |
| Gene ID | 20375 |
|---|---|
| Alias Symbol | Dis-1, Dis1, PU.1, Sfpi-1, Spi-1, Spi1, Tcfpu1, Tfpu.1, Sfpi1 |
| Other Names | Transcription factor PU.1, 31 kDa-transforming protein, SFFV proviral integration 1 protein, Spi1, Sfpi-1, Sfpi1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Sfpi1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Sfpi1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Spi1 |
|---|---|
| Synonyms | Sfpi-1 {ECO:0000303|PubMed:1985210}, Sfp |
| Function | Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites (PubMed:8079170). Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:8079170). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:2180582). In vitro can bind RNA and interfere with pre-mRNA splicing (PubMed:8626664). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P17947}. |
| Tissue Location | Expressed in spleen, thymus and bone-marrow macrophages. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI11133
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