|Other Accession||NM_012029, NP_036159|
|Other Names||Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial, Protein SITPEC, Ecsit, Sitpec|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Ecsit antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Ecsit antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.|
|Cellular Location||Cytoplasm. Nucleus. Mitochondrion|
|Tissue Location||Detected in heart, brain, lung, liver, skeletal muscle, kidney and testis. Detected in embryonic mesoderm and epiblast, and in extraembryonic ectoderm|
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