|Application ||WB, IHC|
|Other Accession||NM_021884, NP_068684|
|Reactivity||Human, Mouse, Rat, Rabbit, Goat, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Goat, Horse, Bovine, Dog|
|Alias Symbol||CC2, AI255943|
|Other Names||Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, Tsg101|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-TSG101 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TSG101 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis (By similarity)|
|Tissue Location||Ubiquitous. Higher expression in brain and mammary gland. Lower expression in liver and tumoral tissues|
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Provided below are standard protocols that you may find useful for product applications.
Stefan,M., (er) BMC Genomics 6, 157 (2005)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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