|Other Accession||NM_028761, NP_083037|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Bovine|
|Alias Symbol||DAN, 1200003I18Rik|
|Other Names||Poly(A)-specific ribonuclease PARN, 22.214.171.124, Polyadenylate-specific ribonuclease, Parn|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-PARN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PARN antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar|
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Provided below are standard protocols that you may find useful for product applications.
Katayama,S., et al., (2005) Science 309 (5740), 1564-1566Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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