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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Zebrafish   >   Fbxw7 antibody - middle region   

Fbxw7 antibody - middle region

Rabbit Polyclonal Antibody

  • IHC - Fbxw7 antibody - middle region AI11220
    Mouse Brain
  • WB - Fbxw7 antibody - middle region AI11220

    WB Suggested Anti-Fbxw7 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Mouse Lung
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8VBV4
Other Accession NM_080428, NP_536353
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog
Predicted Human, Mouse, Rabbit, Zebrafish, Chicken, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Additional Information
Gene ID 50754
Alias Symbol 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Other Names F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7 {ECO:0000312|MGI:MGI:1354695}, F-box protein FBW7, F-box protein Fbxw6, F-box-WD40 repeat protein 6, SEL-10, Fbxw7 {ECO:0000312|MGI:MGI:1354695}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Fbxw7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFbxw7 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Fbxw7 {ECO:0000312|MGI:MGI:1354695}
Function Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation.
Cellular Location Nucleus, nucleoplasm
Tissue Location Widely expressed with highest levels in brain, heart and testis.
Research Areas
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$ 293.00
Cat# AI11220
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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