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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > Fbxw7 antibody - middle region
Fbxw7 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8VBV4 |
| Other Accession | NM_080428, NP_536353 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rabbit, Zebrafish, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70kDa |
| Gene ID | 50754 |
|---|---|
| Alias Symbol | 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10 |
| Other Names | F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7 {ECO:0000312|MGI:MGI:1354695}, F-box protein FBW7, F-box protein Fbxw6, F-box-WD40 repeat protein 6, SEL-10, Fbxw7 {ECO:0000312|MGI:MGI:1354695} |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Fbxw7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Fbxw7 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Fbxw7 {ECO:0000312|MGI:MGI:1354695} |
|---|---|
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924). Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, MLST8, RICTOR and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity). |
| Cellular Location | Nucleus, nucleoplasm. Chromosome {ECO:0000250|UniProtKB:Q969H0}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM {ECO:0000250|UniProtKB:Q969H0} |
| Tissue Location | Widely expressed with highest levels in brain, heart and testis. |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI11220
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