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Ptges2 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8BWM0 |
| Other Accession | NM_133783, NP_598544 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Gene ID | 96979 |
|---|---|
| Alias Symbol | 0610038H10Rik, C79137, Gbf1, Mpges2, Pges2 |
| Other Names | Prostaglandin E synthase 2, 5.3.99.3, GATE-binding factor 1, GBF-1, Microsomal prostaglandin E synthase 2, mPGES-2, Prostaglandin E synthase 2 truncated form, Ptges2, Gbf1, Pges2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ptges2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ptges2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ptges2 |
|---|---|
| Synonyms | Gbf1, Pges2 |
| Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). May also have transactivation activity toward IFN- gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear (PubMed:12050152). |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H7Z7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H7Z7}. Nucleus Note=According to PubMed:12050152, some fraction may be nuclear |
| Tissue Location | Widely expressed. Expressed in brain, heart, liver, colon and lung. |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI11226
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