|Other Accession||NM_153049, NP_694629|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||Mal, AMKL, Bsac, Mrtf-A, AI852829, AW743281, AW821984|
|Other Names||MKL/myocardin-like protein 1, Basic SAP coiled-coil transcription activator, Megakaryoblastic leukemia 1 protein homolog, Myocardin-related transcription factor A, MRTF-A, Mkl1, Bsac|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-MKL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MKL1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (By similarity).|
|Tissue Location||Expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis|
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Provided below are standard protocols that you may find useful for product applications.
Sasazuki,T., et al., (2002) J. Biol. Chem. 277 (32), 28853-28860Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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