Cbfa2t2 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O70374 |
Other Accession | NM_172860, NP_766448 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 66kDa |
Gene ID | 12396 |
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Alias Symbol | A430091M07, C330013D05Rik, Cbfa2t2h, MTGR1 |
Other Names | Protein CBFA2T2, MTG8-like protein, MTG8-related protein 1, Cbfa2t2, Cbfa2t2h, Mtgr1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Cbfa2t2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Cbfa2t2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Cbfa2t2 |
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Synonyms | Cbfa2t2h, Mtgr1 |
Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00440}. |
Tissue Location | Expressed in embryonic stem cells. |
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