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Cbfa2t2 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Cbfa2t2 antibody - middle region AI11244

    WB Suggested Anti-Cbfa2t2 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:1562500
    Positive Control: Mouse Brain
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O70374
Other Accession NM_172860, NP_766448
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 66kDa
Additional Information
Gene ID 12396
Alias Symbol A430091M07, C330013D05Rik, Cbfa2t2h, MTGR1
Other Names Protein CBFA2T2, MTG8-like protein, MTG8-related protein 1, Cbfa2t2, Cbfa2t2h, Mtgr1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Cbfa2t2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCbfa2t2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cbfa2t2
Synonyms Cbfa2t2h, Mtgr1
Function Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization- dependent mannerCan repress the expression of MMP7 in a ZBTB33- dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00440}
Tissue Location Expressed in embryonic stem cells.
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$ 293.00
Cat# AI11244
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