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>   home   >   Products   >   Primary Antibodies   >   FOXK1 antibody - C-terminal region   

FOXK1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - FOXK1 antibody - C-terminal region AI11281
    Mouse Kidney
  • WB - FOXK1 antibody - C-terminal region AI11281

    WB Suggested Anti-FOXK1 Antibody Titration: 2.5μg/ml
    Positive Control: NIH/3T3 cell lysate
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P42128
Other Accession NM_199068, NP_951031
Reactivity Mouse, Rat
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 68kDa
Additional Information
Gene ID 17425
Alias Symbol Mnf, Gm10868, AI463295, A630048H08Rik, ENSMUSG00000075577
Other Names Forkhead box protein K1, Myocyte nuclear factor, MNF, Foxk1, Mnf
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-FOXK1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFOXK1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Foxk1
Synonyms Mnf
Function Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Important regulatory factor of the myogenic progenitor cell population. Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells. Represses myogenic differentiation by inhibiting MEFC acitivity. Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (PubMed:10792059). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P85037, ECO:0000305}
Tissue Location Expressed in tissues and cells in which the myoglobin gene is transcriptionally active including cardiac and skeletal myocytes, brain and kidney. In the adult brain, expressed in the piriform cortex and the indusium griseum. In the hippocampus, expression is localized to the dentate gyrus and CA3 area. In the cerebellum, expression is confined to the Purkinje cell layer.
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References

Wijchers,P.J., (2006) Brain Res. 1068 (1), 23-33Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 232.00
Cat# AI11281
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