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Sox10 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Sox10 antibody - N-terminal region AI11285

    WB Suggested Anti-Sox10 Antibody Titration: 0.2-1 μg/ml
    Positive Control: SP2/0 cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q04888
Other Accession XM_128139, XP_128139
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 63kDa
Additional Information
Gene ID 20665
Alias Symbol Dom, Sox21
Other Names Transcription factor SOX-10, Protein SOX-21, Transcription factor SOX-M, Sox10, Sox-10, Sox21
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Sox10 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSox10 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sox10
Synonyms Sox-10, Sox21
Function Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
Cellular Location Cytoplasm. Nucleus Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in oligodendroglia of the spinal tube (at protein level).
Citations (0)
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$ 389.00
Cat# AI11285
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