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ZNF598 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - ZNF598 antibody - middle region AI11314

    WB Suggested Anti-ZNF598 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: 721_B cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q86UK7
Other Accession NM_178167, NP_835461
Reactivity Human, Mouse, Rat, Horse, Dog
Predicted Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 99kDa
Additional Information
Gene ID 90850
Alias Symbol DKFZp762F135, FLJ00086
Other Names Zinc finger protein 598, ZNF598
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ZNF598 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsZNF598 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF598 {ECO:0000303|PubMed:28132843, ECO:0000312|HGNC:HGNC:28079}
Function E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32579943, PubMed:32099016, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32579943, PubMed:32099016, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin- conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242).
Cellular Location Cytoplasm, cytosol.
Citations (0)
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References

Tao,W.A., (2005) Nat. Methods 2 (8), 591-598 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 389.00
Cat# AI11314
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