|Other Accession||NM_009189, NP_033215|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Zebrafish, Pig, Chicken, Sheep, Bovine, Dog|
|Other Names||Homeobox protein SIX1, Sine oculis homeobox homolog 1, Six1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Six1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Six1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1- DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed in phalangeal tendons and in skeletal muscle and in head and body mesenchyme|
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