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Six1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • IHC - Six1 antibody - N-terminal region AI11450
    Rabbit Anti-Six1 Antibody
    Catalog Number: AI11450
    Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Cytoplasmic,Nuclear (very rare in Nuclear)
    Primary Antibody
    Concentration: 1:600
    Secondary Antibody: Donkey anti-Rabbit-Cy2/3
    Secondary Antibody
    Concentration: 1:200
    Magnification: 20X
    Exposure Time: 0.5 – 2.0 sec
    Protocol located in Reviews and Data.
  • WB - Six1 antibody - N-terminal region AI11450

    WB Suggested Anti-Six1 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Kidney
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q62231
Other Accession NM_009189, NP_033215
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Zebrafish, Pig, Chicken, Sheep, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Additional Information
Gene ID 20471
Alias Symbol BB138287
Other Names Homeobox protein SIX1, Sine oculis homeobox homolog 1, Six1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Six1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSix1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Six1
Function Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1- DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Expressed in phalangeal tendons and in skeletal muscle and in head and body mesenchyme
Research Areas
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$ 293.00
Cat# AI11450
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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