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Hdac6 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • CHIP - Hdac6 Antibody - C-terminal region AI11451
    Chromatin Immunoprecipitation (ChIP) Using Hdac6 Antibody - C-terminal region (AI11451) and HCT116 Cells
    detail
  • IHC - Hdac6 Antibody - C-terminal region AI11451
    Rabbit Anti-Hdac6 Antibody
    Catalog Number: AI11451
    Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Cytoplasmic
    Primary Antibody
    Concentration: 1:600
    Secondary Antibody: Donkey anti-Rabbit-Cy2/3
    Secondary Antibody
    Concentration: 1:200
    Magnification: 20X
    Exposure Time: 0.5 – 2.0 sec
    Protocol located in Reviews and Data.
    detail
  • WB - Hdac6 Antibody - C-terminal region AI11451

    WB Suggested Anti-Hdac6 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Testis
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, CHIP
Primary Accession Q9Z2V5
Other Accession NM_010413, NP_034543
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 126kDa
Additional Information
Gene ID 15185
Alias Symbol Hd6, Hdac5, Sfc6, mHDA2
Other Names Histone deacetylase 6, HD6, 3.5.1.98, Histone deacetylase mHDA2, Hdac6
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Hdac6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHdac6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Hdac6 {ECO:0000312|MGI:MGI:1333752}
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:9891014). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:19893491, PubMed:27737934). Required for cilia disassembly; via deacetylation of alpha-tubulin (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (PubMed:35922041). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin- proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:22819792).
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Perikaryon Cell projection, dendrite. Cell projection, axon. Cell projection, cilium {ECO:0000250|UniProtKB:Q9UBN7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9UBN7} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9UBN7}. Note=It is mainly cytoplasmic, where it is associated with microtubules.
Tissue Location Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level)
Research Areas
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$ 389.00
Cat# AI11451
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