|Application ||WB, CHIP|
|Other Accession||NM_010413, NP_034543|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Dog|
|Alias Symbol||Hd6, Hdac5, Sfc6, mHDA2|
|Other Names||Histone deacetylase 6, HD6, 18.104.22.168, Histone deacetylase mHDA2, Hdac6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Hdac6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Hdac6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.|
|Cellular Location||Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=It is mainly cytoplasmic, where it is associated with microtubules|
|Tissue Location||Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level)|
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