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TRIM16 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - TRIM16 antibody - N-terminal region AI11465

    WB Suggested Anti-TRIM16 Antibody Titration: 1.25μg/ml
    ELISA Titer: 1:62500
    Positive Control: HepG2 cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O95361
Other Accession NM_006470, NP_006461
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Additional Information
Gene ID 10626
Alias Symbol EBBP
Other Names Tripartite motif-containing protein 16, Estrogen-responsive B box protein, TRIM16, EBBP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-TRIM16 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTRIM16 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM16
Synonyms EBBP
Function E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Cellular Location Cytoplasm.
Tissue Location Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes
Citations (0)
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References

Beer,H.D., (2002) J. Biol. Chem. 277 (23), 20740-20749Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 339.00
Cat# AI11465
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