|Other Accession||NM_017415, NP_059111|
|Reactivity||Human, Rat, Rabbit, Bovine, Dog|
|Predicted||Human, Rabbit, Bovine, Dog|
|Other Names||Kelch-like protein 3, KLHL3, KIAA1129|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-KLHL3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KLHL3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytosol|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Lai,F., et al., (2000) Genomics 66 (1), 65-75Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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