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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   HIF1AN antibody - N-terminal region   

HIF1AN antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - HIF1AN antibody - N-terminal region AI11526

    WB Suggested Anti-HIF1AN Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: Jurkat cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NWT6
Other Accession NM_017902, NP_060372
Reactivity Human, Rabbit, Pig, Horse
Predicted Human, Rabbit, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Additional Information
Gene ID 55662
Alias Symbol FIH1
Other Names Hypoxia-inducible factor 1-alpha inhibitor,, 1.14.11.n4, Factor inhibiting HIF-1, FIH-1, Hypoxia-inducible factor asparagine hydroxylase, HIF1AN, FIH1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HIF1AN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHIF1AN antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FIH1
Function Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages
Research Areas
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Linke,S., et al., (2004) J. Biol. Chem. 279 (14), 14391-14397Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 293.00
Cat# AI11526
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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