UTX antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O15550 |
Other Accession | NM_021140, NP_066963 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog |
Predicted | Human, Zebrafish |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 154kDa |
Gene ID | 7403 |
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Alias Symbol | DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2 |
Other Names | Lysine-specific demethylase 6A, 1.14.11.-, Histone demethylase UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, KDM6A, UTX |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-UTX antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | UTX antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KDM6A |
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Synonyms | UTX |
Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
Hong,S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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