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Klhl12 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - Klhl12 antibody - N-terminal region AI11564

    WB Suggested Anti-Klhl12 Antibody Titration: 1.0 μg/ml
    Positive Control: Rat Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8R2H4
Other Accession NM_153730, NP_714952
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog
Predicted Human, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Additional Information
Gene ID 266772
Alias Symbol C3ip1, MGC93127
Other Names Kelch-like protein 12, CUL3-interacting protein 1, Klhl12, C3ip1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Klhl12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsKlhl12 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Klhl12
Synonyms C3ip1
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).
Cellular Location Cytoplasmic vesicle, COPII-coated vesicle
Research Areas
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$ 293.00
Cat# AI11564
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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