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Ppargc1a antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Ppargc1a antibody - middle region AI11678
    Ppargc1a antibody - middle region (AI11678) validated by WB using Transfected Melanoma Cell at 1:1000.
  • WB - Ppargc1a antibody - middle region AI11678

    Host: Rabbit
    Target Name:Ppargc1a
    Sample Tissue:SP2/0
    Lane A: Primary Antibody
    Lane B: Primary Antibody + Blocking Peptide
    Primary Antibody
    Peptide Concentration: 5μg/ml
    Lysate Quantity: 25ug/lane Gel
    Concentration: 0.12%
  • WB - Ppargc1a antibody - middle region AI11678

    WB Suggested Anti-Ppargc1a Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: SP2/0 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O70343
Other Accession NM_008904, NP_032930
Reactivity Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Dog
Predicted Human, Mouse, Rabbit, Pig, Goat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 90kDa
Additional Information
Gene ID 19017
Alias Symbol A830037N07Rik, PGC-1, PGC-1v, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, Gm11133, ENSMUSG00000079510
Other Names Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ppargc1a, Pgc1, Pgc1a, Ppargc1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ppargc1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPpargc1a antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ppargc1a
Synonyms Pgc1, Pgc1a, Ppargc1
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy.
Cellular Location Nucleus. Nucleus, PML body.
Tissue Location White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level). Skeletal muscle, brown adipose tissue, heart, kidney and brain.
Research Areas
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Finck,B.N. (2006) J. Clin. Invest. 116 (3), 615-622Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 293.00
Cat# AI11678
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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