|Other Accession||NM_016133, NP_057217|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Dog|
|Predicted||Mouse, Rabbit, Pig, Goat, Bovine|
|Other Names||Insulin-induced gene 2 protein, INSIG-2, INSIG2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-INSIG2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||INSIG2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Li,C.G., (2008) Int. J. Cancer 123 (2), 273-282 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Yu, Z. et al. Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver. J. Gerontol. A. Biol. Sci. Med. Sci. glu053- (2014). doi:10.1093/gerona/glu053 WB, Bovine, H, Goat, Rabbit, Sheep, Human, Pig, Mouse, Dog, Rat24755936
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