|Other Accession||NM_013595, NP_038623|
|Reactivity||Human, Mouse, Rat, Dog|
|Alias Symbol||AI181826, AU019209|
|Other Names||Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, Mbd3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Mbd3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Mbd3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases.|
|Cellular Location||Nucleus. Chromosome Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci.|
|Tissue Location||Highly expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells.|
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