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Mbd3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Z2D8 |
| Other Accession | NM_013595, NP_038623 |
| Reactivity | Human, Mouse, Rat, Dog |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32kDa |
| Gene ID | 17192 |
|---|---|
| Alias Symbol | AI181826, AU019209 |
| Other Names | Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, Mbd3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Mbd3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Mbd3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Mbd3 |
|---|---|
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Does not bind methylated DNA by itself (PubMed:9774669). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases (By similarity). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:O95983} Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci (PubMed:9774669) {ECO:0000250|UniProtKB:O95983, ECO:0000269|PubMed:9774669} |
| Tissue Location | Highly expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI11692
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