|Application ||WB, IHC|
|Other Accession||NM_001535, NP_001526|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Horse, Bovine, Dog|
|Other Names||Protein arginine N-methyltransferase 2, 2.1.1.-, Histone-arginine N-methyltransferase PRMT2, 220.127.116.11, PRMT2, HMT1, HRMT1L1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-PRMT2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PRMT2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus Isoform PRMT2L2: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic|
|Tissue Location||Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.|
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