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PSMA1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - PSMA1 antibody - C-terminal region AI11746
    Rabbit Anti-PSMA1 Antibody
    Catalog Number: AI11746
    Formalin Fixed Paraffin Embedded Tissue: Human Bronchial Epithelial Tissue Observed Staining: Cytoplasmic
    Primary Antibody
    Concentration: 1:100
    Secondary Antibody: Donkey anti-Rabbit-Cy3
    Secondary Antibody
    Concentration: 1:200
    Magnification: 20X
    Exposure Time: 0.5 - 2.0 sec
    detail
  • WB - PSMA1 antibody - C-terminal region AI11746

    WB Suggested Anti-PSMA1 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Jurkat cell lysate
    detail
  • WB - PSMA1 antibody - C-terminal region AI11746

    Sample Type: Human non-small cell lung cancer (NCI-460)Primary Dilution: 1:2000Secondary Dilution: 1:300050kDa band is a tubulin loading control bandPSMA1 is strongly supported by BioGPS gene expression data to be expressed in Human NCI460 cells
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P25786
Other Accession NM_002786, NP_002777
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Zebrafish, Chicken, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 29kDa
Additional Information
Gene ID 5682
Alias Symbol HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30
Other Names Proteasome subunit alpha type-1, 3.4.25.1, 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, PSMA1, HC2, NU, PROS30, PSC2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-PSMA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPSMA1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMA1
Synonyms HC2, NU, PROS30, PSC2
Function Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Cellular Location Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9
Research Areas
Citations (0)
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References

Conticello,S.G., (2003) Curr. Biol. 13 (22), 2009-2013 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Cron, K. R. et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 8, e73710 (2013). WB, Pig, Human, H, Rabbit, Rat, Guinea pig, Dog, Bovine, Mouse, Zebrafish24040035

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$ 389.00
Cat# AI11746
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