|Other Accession||NM_002936, NP_002927|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Yeast, Bovine, Dog|
|Predicted||Human, Mouse, Bovine, Dog|
|Alias Symbol||H1RNA, RNH1|
|Other Names||Ribonuclease H1, RNase H1, 22.214.171.124, Ribonuclease H type II, RNASEH1, RNH1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RNASEH1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RNASEH1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224).|
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Provided below are standard protocols that you may find useful for product applications.
Nowotny,M., (2008) EMBO J. 27 (7), 1172-1181 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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