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CPNE1 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - CPNE1 antibody - middle region AI11757

    Host:Rabbit
    Target Name:CPNE1
    Sample Tissue:Human Hela
    Antibody Dilution: 1.0μg/mlCPNE1 is supported by BioGPS gene expression data to be expressed in HeLa
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q99829
Other Accession NM_003915, NP_003906
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog
Predicted Human, Mouse, Rabbit, Zebrafish, Pig, Chicken, Sheep, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 59kDa
Additional Information
Gene ID 8904
Alias Symbol COPN1, CPN1, MGC1142
Other Names Copine-1, Copine I, CPNE1, CPN1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CPNE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCPNE1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPNE1 (HGNC:2314)
Synonyms CPN1
Function Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha- induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
Cellular Location Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).
Tissue Location Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).
Research Areas
Citations (0)

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References

Ma,J., (2007) Atherosclerosis 191 (1), 63-72 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 293.00
Cat# AI11757
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