|Application ||WB, IHC|
|Other Accession||NM_003915, NP_003906|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rabbit, Pig, Chicken, Sheep, Horse, Bovine, Dog|
|Alias Symbol||CPN1, COPN1|
|Other Names||Copine-1, Copine I, CPNE1, CPN1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-CPNE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CPNE1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha- induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).|
|Tissue Location||Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).|
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Provided below are standard protocols that you may find useful for product applications.
Tomsig,J.L., Biochem. J. 378 (PT 3), 1089-1094 (2004)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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