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CPNE1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - CPNE1 antibody - N-terminal region AI11758
    Rabbit Anti-CPNE1 Antibody
    Paraffin Embedded Tissue: Human Intestine
    Cellular Data: Epithelial cells of intestinal villas
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
  • WB - CPNE1 antibody - N-terminal region AI11758

    WB Suggested Anti-CPNE1 Antibody Titration: 5.0μg/ml
    Positive Control: HepG2 cell lysate
    CPNE1 is supported by BioGPS gene expression data to be expressed in HepG2
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q99829
Other Accession NM_003915, NP_003906
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog
Predicted Human, Mouse, Rabbit, Pig, Chicken, Sheep, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 59kDa
Additional Information
Gene ID 8904
Alias Symbol CPN1, COPN1
Other Names Copine-1, Copine I, CPNE1, CPN1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-CPNE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCPNE1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPNE1 (HGNC:2314)
Synonyms CPN1
Function Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha- induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
Cellular Location Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).
Tissue Location Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).
Research Areas
Citations (0)

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References

Tomsig,J.L., Biochem. J. 378 (PT 3), 1089-1094 (2004)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 232.00
Cat# AI11758
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