|Other Accession||NM_001177650, NP_001171121|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Bovine|
|Alias Symbol||1110057E06Rik, 2210010H06Rik, FBP1, Fbp17|
|Other Names||Formin-binding protein 1, Formin-binding protein 17, Fnbp1, Fbp17, Kiaa0554|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Fnbp1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Fnbp1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes|
|Tissue Location||Expressed in brain and testis.|
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