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TNRC6B antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UPQ9 |
| Other Accession | NM_015088, NP_055903 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
| Predicted | Human, Rat, Rabbit, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 183kDa |
| Gene ID | 23112 |
|---|---|
| Alias Symbol | KIAA1093 |
| Other Names | Trinucleotide repeat-containing gene 6B protein, TNRC6B, KIAA1093 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TNRC6B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TNRC6B antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNRC6B |
|---|---|
| Synonyms | KIAA1093 |
| Function | Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA- dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). |
| Cellular Location | Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs). |
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Provided below are standard protocols that you may find useful for product applications.
References
Schneider,M.D., (2006) J. Cell Biol. 174 (3), 349-358 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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