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Mbnl2 Antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Mbnl2 Antibody - middle region AI11828

    Host: Rabbit
    Target Name: Mbnl2
    Sample Tissue: Rat Brain lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession F2Z3T4
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Additional Information
Gene ID 680445
Other Names Muscleblind-like protein 2, Mbnl2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-Mbnl2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMbnl2 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mbnl2
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Greater concentration in the nucleus Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent (By similarity)
Tissue Location Expressed in the cerebellum, pineal gland and skeletal muscle. In the pineal gland, expressed in pinealocytes, not in perivascular spaces (at protein level)
Research Areas
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$ 293.00
Cat# AI11828
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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