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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > Rbm25 antibody - middle region
Rbm25 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | B2RY56 |
| Other Accession | NM_027349, NP_081625 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Yeast, Bovine, Dog |
| Predicted | Human, Mouse, Rabbit, Zebrafish, Chicken, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 99kDa |
| Gene ID | 67039 |
|---|---|
| Alias Symbol | 2600011C06Rik, 2610015J01Rik, A130095G20Rik, AI159652, AL023075, AU043498, RNPC7 |
| Other Names | RNA-binding protein 25, RNA-binding motif protein 25, Rbm25 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Rbm25 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Rbm25 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Rbm25 |
|---|---|
| Function | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA (By similarity). |
| Cellular Location | Nucleus speckle {ECO:0000255|PROSITE- ProRule:PRU00627}. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint (By similarity) |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI11832
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