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MGC42174 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8IYB7 |
| Other Accession | NM_152383, NP_689596 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 68kDa |
| Gene ID | 129563 |
|---|---|
| Alias Symbol | FAM6A, MGC42174 |
| Other Names | DIS3-like exonuclease 2 {ECO:0000255|HAMAP-Rule:MF_03045}, hDIS3L2, 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_03045}, DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045}, FAM6A |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-MGC42174 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MGC42174 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DIS3L2 {ECO:0000255|HAMAP-Rule:MF_03045} |
|---|---|
| Synonyms | FAM6A |
| Function | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Ota,T., (2004) Nat. Genet. 36 (1), 40-45Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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