|Other Accession||NM_021205, NP_067028|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rabbit, Chicken, Horse, Bovine, Dog|
|Alias Symbol||ARHU, CDC42L1, DJ646B12.2, FLJ10616, WRCH1, fJ646B12.2, hG28K|
|Other Names||Rho-related GTP-binding protein RhoU, CDC42-like GTPase 1, GTP-binding protein-like 1, Rho GTPase-like protein ARHU, Ryu GTPase, Wnt-1 responsive Cdc42 homolog 1, WRCH-1, RHOU (HGNC:17794)|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RHOU antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RHOU antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.|
|Cellular Location||Cell membrane; Lipid- anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC- transformed cells.|
|Tissue Location||Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Chuang,Y.Y., J. Cell. Sci. 120 (PT 11), 1927-1934 (2007)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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