|Application ||WB, IHC, IP|
|Other Accession||NM_017588, NP_060058|
|Reactivity||Human, Mouse, Rat, Zebrafish, Pig, Horse, Yeast, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Zebrafish, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||BIG-3, SWD3|
|Other Names||WD repeat-containing protein 5, wdr5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-WDR5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||WDR5 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).|
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