|Application ||WB, IHC|
|Other Accession||NM_000962, NP_000953|
|Reactivity||Human, Mouse, Rat, Pig, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Horse, Dog|
|Alias Symbol||COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS|
|Other Names||Prostaglandin G/H synthase 1, 220.127.116.11, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1, PTGS1, COX1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-PTGS1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PTGS1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.|
|Cellular Location||Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein|
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