|Other Accession||NM_005041, NP_005032|
|Reactivity||Human, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Pig, Horse, Bovine, Dog|
|Alias Symbol||FLH2, HPLH2, MGC65093, P1, PFP, PFN1|
|Other Names||Perforin-1, P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, PFP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PRF1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PRF1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.|
|Cellular Location||Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes|
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Provided below are standard protocols that you may find useful for product applications.
Okur,H., (2008) Leuk. Res. 32 (6), 972-975 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.