|Other Accession||NM_153832, NP_722561|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||FLJ33952, RE2|
|Other Names||G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GPR161 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GPR161 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).|
|Cellular Location||Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Gregory,S.G., (2006) Nature 441 (7091), 315-321 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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