|Other Accession||NM_019426, NP_062299|
|Reactivity||Mouse, Rat, Pig|
|Predicted||Mouse, Rat, Pig|
|Alias Symbol||2610204M12Rik, AM, Mcaf1|
|Other Names||Activating transcription factor 7-interacting protein 1, ATFa-associated modulator, mAM, MBD1-containing chromatin-associated factor 1, Atf7ip, Mcaf1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Atf7ip antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Atf7ip Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). May have ATPase activity.|
|Tissue Location||Ubiquitously expressed at all stages studied.|
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