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Atf7ip Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q7TT18 |
| Other Accession | NM_019426, NP_062299 |
| Reactivity | Mouse, Rat, Pig |
| Predicted | Mouse, Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 138kDa |
| Gene ID | 54343 |
|---|---|
| Alias Symbol | 2610204M12Rik, AM, Mcaf1 |
| Other Names | Activating transcription factor 7-interacting protein 1, ATFa-associated modulator, mAM, MBD1-containing chromatin-associated factor 1, Atf7ip, Mcaf1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Atf7ip antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Atf7ip Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Atf7ip |
|---|---|
| Synonyms | Mcaf1 |
| Function | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context (PubMed:10777215). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed at all stages studied. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12052
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